Applications of Time-of-Flight and Orbitrap Mass by Sandra Perez, Peter Eichhorn, Damia Barcelo PDF

By Sandra Perez, Peter Eichhorn, Damia Barcelo

ISBN-10: 0444635726

ISBN-13: 9780444635723

Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, nutrients, Doping, and Forensic Analysis bargains with using high-resolution mass spectrometry (MS) within the research of small natural molecules. during the last few years, time-of-flight (ToF) and Orbitrap MS have either skilled great progress in various analytical sectors and are actually good verified in lots of laboratories the place excessive necessities are put on analytical functionality.

This booklet provides a head-to-head comparability of those applied sciences that compete at once with one another. As clients with hands-on event in either ideas, the authors offer a balanced description of the strengths and weaknesses of either options. within the overwhelming majority of situations, ToF-MS and Orbitrap-MS were used for qualitative reasons, in most cases id of discrete molecular entities reminiscent of drug metabolites or transformation items of environmental contaminants.

This paradigm is now altering as quantitative services are more and more being explored, as are non-target techniques for independent broad-scope screening. In view of the continual innovation of high-resolution MS software brands in designing and constructing extra strong machines, technological advances in either and software program are significant, with many novel purposes.

This publication summarizes and analyzes those traits. The compilation of chosen examples from different analytical fields will permit the readers to find not just the possibility of high-resolution MS of their area, but in addition indicates advances in different fields that depend upon hi-res MS.

  • Provides finished insurance of functions of time-of-flight and orbitrap mass spectrometry in environmental, foodstuff, doping, and forensic analysis
  • Explores quite a few really expert concepts, giving a balanced description of the strengths and weaknesses of each
  • Presents a normal evaluate of imaging concepts inside analysis

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Additional info for Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis

Example text

FIGURE 5 Relative response of reserpine using Agilent Jet Stream versus Standard ESI. Advances in Time-of-Flight Mass Spectrometry Chapter j 2 29 It is generally accepted that an increase in the amount of atmospheric gas that is sampled through the primary orifice, or sampling capillary, has a proportional effect on ion sampling efficiency. This presents two challenges to the mass spectrometer design. The first is for the instrument vacuum system to be able to handle the increased gas load and the second is to be able to efficiently capture and transmit these ions through to the mass spectrometer analyser under this increased pressure.

The instrument was equipped with an 24 SECTION j I Instrumentation ESI source, quadrupole mass filter, hexapole collision cell, orthogonal ion pusher, single-field reflectron ion mirror, microchannel plate (MCP) detector and time-to-digital signal converter e many of the same design elements found in today’s Q-TOF instruments as shown in Fig. 3. The Micromass Q-TOF achieved a resolving power of 5000. Within a short time period several other manufacturers, including Perceptive, Analytica of Branford, Sensar and JEOL, introduced electrospray TOF.

The Q-TOF had a resolving power of 40,000 at m/z 1521 and a typical resolving power at m/z 314 of 31,000. The orbitrap was operated in the 100,000 resolution mode and had a resolving power of 75,000 at m/z 314, greater than that for the Q-TOF. The degree of analyte separation provided by the chromatographic system was varied with LC runs taking between 30 and 70 min. The results from the 30-min gradient LC run found that the lower resolving power Q-TOF was able to find 230 out 232 potentially identifiable analytes, whereas the orbitrap found 53 analytes.

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Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis by Sandra Perez, Peter Eichhorn, Damia Barcelo


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