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Elegans Gq␣ gene disrupt movement, egg laying, and viability. Neuron 16: 999–1009. C. elegans Sequencing Consortium, 1998 Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282: 2012–2018. Chase, D. , G. A. Patikoglou and M. R. Koelle, 2001 Two RGS proteins that inhibit G␣o and G␣q signaling in C. elegans neurons require a G␤5-like subunit for function. Curr. Biol. 11: 222–231. Dessauer, C. , T. T. Scully and A. G. Gilman, 1997 Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase.

Nat Rev Mol Cell Biol 3: 639-650. PIERCE-SHIMOMURA, J. , S. FAUMONT , M. R. GASTON, B. J. PEARSON and S. R. LOCKERY, 2001 The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans. Nature 410: 694-698. 30 Introduction P ITCHER , J. , N. J. FREEDMAN and R. J. LEFKOWITZ , 1998 G protein-coupled receptor kinases. Annu Rev Biochem 67: 653-692. PLASTERK, R. , 1995 Reverse genetics: from gene sequence to mutant worm. Methods Cell Biol 48: 59-80. P LOWMAN , G. , S. SUDARSANAM , J.

And T. M. WILKIE , 2000 GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69: 795-827. RUSHFORTH, A. , and P. ANDERSON, 1996 Splicing removes the Caenorhabditis elegans transposon Tc1 from most mutant pre-mRNAs. Mol Cell Biol 16: 422-429. RUSHFORTH, A. , B. SAARI and P. ANDERSON, 1993 Site-selected insertion of the transposon Tc1 into a Caenorhabditis elegans myosin light chain gene. Mol Cell Biol 13: 902-910.

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