By Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)
Alcohol abuse and alcoholism are foreign difficulties whose expenditures comparatively cheap ly, psychologically and medically were good documented. Alcohol is a special drug in that the consequences of over the top use could have a deleterious impact on such a lot if now not all organs of the physique. The mind is among the organs most influenced by way of over the top alcohol intake. results at the mind might be visible in cognitive functionality, mind constitution and neurochemistry. during the last few years, there were major advances made in figuring out how alcohol impacts mind neurochemistry. This e-book examines 4 significant components, i. e. , membrane lipids, receptors and ion channels, moment messengers, and gene expression, the place major developments were made. The publication is split into 4 sections according to the 4 significant parts. In every one part, information are tested that disguise a number of methods from in vitro to in vivo stories. The part on membrane lipids comprises fresh advancements in how ethanol impacts membrane ldl cholesterol domain names, polyunsaturated fatty acids, the reason and outcomes of phosphatidylethanol formation, and the modulation of membrane protein functionality by means of lipid-protein interplay. the second one part includes chapters on NMDA and 5-HT3 receptors, together with new features on alcohol neurotoxicity and the molecular heterogeneity that could underlie modifications in alcohol sensitivity in addition to chapters on GABA-gated chloride flux, and calcium channels.
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Extra resources for Alcohol, Cell Membranes, and Signal Transduction in Brain
Biochem I 250. 653. Stubbs. W. Williams. CL. Prya' and E. Rubin. 1988. me interactions. Arch. Biochem. Biophys. 262. 560. Sun. Y. Y. Sun. 1985. Ethanol and membrane lipids. 164. Supernovich. • R. Crain and P. Rosenberg. 1991a, PhosphatidylchoOOe asymmetry in electroplax from the electric eel: Use of a phosphatidylcholine exchange protein. J. Neurochem 57. 575. Supemovich. • R. Crain and P. Rosenberg. 1991b. Effect of soman and sarin on phosphatidylcholine asymmetry in the electroplax from the electric eel.
1979) and synaptic plasma 37 Table 3. Effects of Ethanol on Polyunsaturated Fatty Acid Composition in the Blood. , 1982 rats drinking water (135 days) serum ,I. -s. P. -s. , 1991 rats liquid diet (21 days) erythrocytes ,I. -s. -s. -s. -s. -s. -s. -s. , 19 1 rats inhalation (6 days) platelets ,I. , 1970 rats drinking water (25 weeks) erythrocytes ,I. -s. -s. ,I. -s. -s. -s. -s. -s. -s. -s. -s. -s. P. -s. -s. , 1981 rats liquid diet (4 weeks) erythrocytes ,I. r. , 1987 rats inhalation (1 day) erythrocytes ,I.
1991). In this study, there was no change in concentrations of 20:4n6 or 22:6n3 in the brain at 10 postnatal days of age while, at 20 days of age, there was an increase in 20:4n6 in the phosphatidylserine fraction. Further research will be needed to elaborate some of the critical factors which must be considered when determining what effect, if any, ethanol exposure during development has on PUFA concentrations in offspring. INHALATION STUDIES From the above discussion, it should be apparent that there are many variables that were often uncontrolled that may lead to differences in the measured effects of alcohol on lipid composition in general and on fatty acyl composition, in particular.
Alcohol, Cell Membranes, and Signal Transduction in Brain by Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)