By M. S. Spach, P. Dolber, J. F. Heidlage (auth.), S. Sideman D.Sc., R. Beyar M.D., D.Sc. (eds.)
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Extra info for Activation, Metabolism and Perfusion of the Heart: Simulation and experimental models
The arrows at the bottom of each panel mark the times of Vmax of the underlying action potentials. The preparation was from a two-year-old male. ) potential at sites 20 to 100 JLm apart (less than a cell length), along the long axis of the fiber and at sites 10 to 20 JLm apart (about a cell diameter) along an axis in the transverse direction. The waveforms and their derivatives maintained a smooth contour and there was a monotonic increase in the local excitation times without evidence of local delays in either direction.
At the top of Panel A the numbers identify each deflection that was accounted for experimentally as being due to an identifiable separate atrial bundle. Panel B shows the simulated fit of the experimental data. The experimental waveforms were measured in a preparation from a 62-year-old subject. See text for description. ) large amplitude of its original potential deflection. The continued progression of the relative changes was especially pronounced in going from the first to the second derivative; the largest second derivative peaks occurred with the smallest original potential deflections, which were produced by sources closest to the observation site.
A plot of Vm(26) and a 2v m/ax2 (27) is given in Fig. 2, for e = 20 em/sec, a crossfiber value frequently reported [10J and which we adopt here in our simulation. Conductivity parameters were derived from the experimental data of Clerc [4 J but with the assumption that cells occupy 80% of the tissue volume, a value currently expected (rather than the 70% assumed by Clerc). 17 X 10- 4 S/mm. 745 is obtained from (24). The evaluation of ct>e can now be made by numerical integration of (25), and this was actually done.
Activation, Metabolism and Perfusion of the Heart: Simulation and experimental models by M. S. Spach, P. Dolber, J. F. Heidlage (auth.), S. Sideman D.Sc., R. Beyar M.D., D.Sc. (eds.)